Structural Heart Disease

Structural Heart Disease

Structural heart disease covers a wide range of cardiac conditions, including valvular heart disease and defects in the muscular structure of the heart. The disease may be congenital, as well as acquired. As the American population ages, acquired disease, such as calcific (senile) aortic stenosis and mitral regurgitation has increased in importance, with 12% of adults over the age of 75 being diagnosed with the disease. The past two decades have seen a revolution in the treatment of structural heart disease with transcatheter therapies being developed for valve repair and replacement, closure of defects such as ASD (atrial septal defects), and isolation of the left atrial appendage to reduce embolic risk in atrial fibrillation. Patients who previously could only undergo high risk surgical aortic valve replacement or were completely inoperable can now be treated with a transcatheter approach, often with only a one night stay in the hospital.

CRF is a leader in research and publications in the area of structural heart disease. The PARTNER Publication Office (PPO), which resides at CRF, facilitates, expedites, coordinates, and executes an aggressive academic publications process from the PARTNER and PARTNER II trials. These trials have led to the approval of the first family of transcatheter aortic valves in the US. The work of the PPO has led to over 85 abstracts being presented, many of them late-breaking main arena presentations at leading scientific meetings, as well as over 60 manuscripts published in top-tier journals such as The New England Journal of Medicine, Journal of the American Medical Association, The Lancet, and Journal of the American College of Cardiology.

We are working on bringing innovative new devices to patients with structural heart disease in a wide range of applications and age groups, from infancy to old age.

Relevant CTC Service Areas for Structural Heart Disease

  • Trial Design
  • Protocol Development
  • Data Management
  • Statistics And Programming
  • Echocardiography Core Lab
  • Hemodynamic Core Lab
  • CT Core Lab
  • CEC
  • DSMB
  • Medical Writing
  • Extended Database Management and Analysis

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