Physician Leadership

CRF’s pioneering research and extensive educational initiatives are guided by visionary physicians who are passionate about advancing the field of interventional cardiology.

Faculty

Martin B. Leon, MD, is Founder and Chairman Emeritus of the Cardiovascular Research Foundation (CRF). He is also Co-Director of Medical Research and Education at CRF. He is Professor of Medicine at Columbia University College of Physicians and Surgeons and Director of the Center for Interventional Vascular Therapy (CIVT) and Cardiac Catheterization Laboratories at NewYork-Presbyterian Hospital/Columbia University Medical Center. In addition, Dr. Leon serves on the Executive Board of the NewYork-Presbyterian/Columbia Heart Valve Center.

A distinguished pioneer in interventional cardiovascular medicine, Dr. Leon has been the principal investigator for over 50 clinical trials that have helped shape the field including STRESS, STARS, Gamma-one, SIRIUS, ENDEAVOR, and most recently, the PARTNER trial, studying the value of transcatheter valve therapy for patients with aortic stenosis.

He is the Founder and Director of Transcatheter Cardiovascular Therapeutics (TCT), the world’s premier meeting dedicated to interventional cardiovascular medicine, which celebrated its 25th anniversary in 2013. He has also been the Director or Co-Director of more than 100 international educational programs in the field. Dr. Leon has received 10 international career achievement awards and was awarded an honorary degree from the University of Athens.

Dr. Leon was previously the Director of Cardiovascular Research and Education at the Lenox Hill Heart and Vascular Institute in New York as well as Director of Clinical Research at the Washington Cardiology Center at the Washington Hospital Center and Clinical Professor of Medicine at Georgetown University Medical Center in Washington, DC. He also served as a Clinical Associate, Senior Investigator, and Director of the Catheterization Laboratories in the Cardiology Branch of the National Heart, Lung and Blood Institute at the National Institutes of Health in Bethesda, Maryland. He was a founder of the Washington Cardiology Center and the Cardiology Research Foundation in Washington, DC.

Dr. Leon received his medical degree from the Yale School of Medicine and completed his internal medicine internship and residency as well as a cardiology fellowship at the Yale-New Haven Hospital.

Gregg W. Stone, MD is Professor of Medicine at the Columbia University Medical Center, Director of Cardiovascular Research and Education at the Center for Interventional Vascular Therapy at New York-Presbyterian Hospital, and Co-Director of Medical Research and Education at the Cardiovascular Research Foundation in New York, NY. Dr. Stone has served as the national or international principal investigator for approximately 100 national and international multicenter randomized trials (many of which have led to new device approval or indications in the US), has authored more than 2000 manuscripts and abstracts published in the peer-reviewed literature as well as numerous book chapters, and has delivered thousands of invited lectures around the world. Dr. Stone's areas of expertise include interventional therapies of acute coronary syndromes and myocardial infarction; drug-eluting stents and bioresorbable scaffolds; left main and complex coronary artery disease intervention; antiplatelet and antithrombotic pharmacotherapies; transcatheter mitral valve repair and replacement; intravascular imaging (IVUS, OCT and NIRS); vulnerable plaque diagnosis and treatment; new device angioplasty including atherectomy, distal embolic protection, thrombectomy, covered stents, chronic total occlusion devices, and brachytherapy; saphenous vein graft therapies; left atrial appendage closure; contrast nephropathy; clinical trial design; and regulatory issues.

Dr. Stone, along with Dr. Martin B. Leon, is the director of Transcatheter Cardiovascular Therapeutics (TCT), the world's largest symposium devoted to interventional cardiology and vascular medicine, founded the annual National Interventional Cardiology Fellow's Course, and co-directs multiple other courses, including Optimizing Complex PCI Outcomes, The Chronic Total Occlusion Summit, The Left Main Summit, Bioresorbable Scaffolds: A Breakthrough PCI Technology, LAA Occlusion: A Technique Oriented Course, and Transcatheter Valve Therapies (TVT). Dr. Stone is also a director or co-director of numerous annual international courses including CIT (China Interventional Therapeutics in Beijing, China), TCTAP (TCT Asia Pacific in Seoul, S. Korea), JIM (Joint Interventional Course in Italy), and TCT Russia (in Moscow).

Dr. Stone's medical practice is devoted to Interventional Cardiology at New York-Presbyterian Hospital and Columbia University Medical Center.

Dr. Stone previously held similar positions at Lenox Hill Hospital in New York and the Washington Hospital Center in Washington, DC. Previously he was the Director of Interventional Cardiology at the Cardiovascular Institute at El Camino Hospital and Stanford University Medical Center in California.

Dr. Stone completed medical school at Johns Hopkins University Medical Center, in Baltimore, MD, and his internship and residency at the New York Hospital-Cornell Medical Center in New York City. He completed his general cardiology fellowship at Cedars-Sinai Medical Center in Los Angeles, CA, under Dr. Jeremy Swan, and subsequently a dedicated fellowship in advanced coronary angioplasty with Dr. Geoffrey O. Hartzler in Kansas City, MO.

Gary S. Mintz, MD, is Chief Medical Officer of the Cardiovascular Research Foundation, Editor- in-Chief of TCTMD.com, and the Managing Co-Director of Transcatheter Cardiovascular Therapeutics (TCT). Dr. Mintz joined the Cardiovascular Research Foundation in 1991. He is the author of more than 900 articles or book chapters and 700 abstracts focusing on intravascular imaging, but also including various aspects of hemodynamics, intravascular physiology, cardiac radiology, coronary arteriography, interventional cardiology, clinical cardiology, and cardiac ultrasound. In 2005, Dr. Mintz published the single-authored textbook Intracoronary Ultrasound. In 2014, he received the “Master of the Masters” career achievement award in Seoul, Korea. In 2015, he received the Chien Foundation Award for Outstanding Lectureship and Lifetime Achievement in PCI at the TCTAP-Cardiovascular Summit in Seoul, Korea. He also serves as co-director of both the annual TCT-AP Cardiovascular Summit and the annual China Interventional Therapeutics in Partnership with TCT.

Dr. Mintz completed his undergraduate education at the University of Pennsylvania in 1970 and received his medical degree from Hahnemann University in 1974, both in Philadelphia, PA. He finished his internship in 1975, residency in 1976, and cardiology fellowship in 1978, each at Hahnemann University. He joined the Hahnemann University Department of Medicine faculty (with a joint appointment in the Department of Diagnostic Radiology) in 1978 and was ultimately promoted to Professor of Medicine in 1987. His administrative appointments there included Director of the Cardiac Ultrasound Laboratory, Director of the Coronary Care Unit, and Director of the Cardiology Fellowship Training Program. He received teaching awards from both the Department of Medicine Residency and Cardiology Fellowship Training Programs.

Ori Ben-Yehuda, MD, is Executive Director of the CRF Clinical Trials Center (CTC). As Executive Director, Dr. Ben-Yehuda is responsible for all CTC activities including trial design, data management, biostatistical analyses, event adjudication, and safety reporting. In addition, he oversees CTC’s CRFiCOR, one of the world’s leading imaging core laboratories.

Dr. Ben-Yehuda was previously Vice President, Cardiovascular Clinical Research at Gilead Sciences. Prior to that, he was Professor of Clinical Medicine at the University of California, San Diego (UCSD) and the Director of the Coronary Care Unit at UCSD Medical Center. He also served as the Deputy Editor of the Journal of the American College of Cardiology from 2002 through 2010.

Dr. Ben-Yehuda received his medical degree from the Sackler School of Medicine at Tel Aviv University in Israel. He completed residencies in internal medicine at the Soroka Medical Center in Beer-Sheba, Israel and New York University Medical Center and Bellevue Hospital in New York. He also finished a cardiovascular medicine fellowship at the University of California, San Diego.

Daniel Burkhoff, MD, PhD, is Director of Heart Failure, Hemodynamics and MCS Research at the Cardiovascular Research Foundation. He is also an Adjunct Associate Professor at Columbia University. A world-renowned expert in heart failure and hemodynamics, Dr. Burkhoff collaborates on heart failure research initiatives across all divisions of CRF. Dr. Burkhoff is author of Harvi, an interactive simulation-based application for teaching and researching many aspects of ventricular mechanics and hemodynamics. Dr. Burkhoff works with the CRF Center for Education to develop novel curricula using Harvi in educational programs for practicing physicians, fellows, and medical students around the world.

Dr. Burkhoff’s interests include cardiovascular modeling and research in basic and clinical aspects of ventricular mechanics, cardiovascular monitoring, heart failure, device and pharmacologic treatments for heart failure, including left ventricular assist devices. He was instrumental in the creation of the CRF Skirball Center for Innovation, and served as Director when it opened in 2005. Before returning to CRF, he was Vice President of Medical Science for HeartWare International. Previously, he served as Medical Director of CircuLite. He received his medical and doctor of philosophy degrees from The Johns Hopkins School of Medicine and completed his cardiology fellowship at The Johns Hopkins Hospital.

George D. Dangas, MD, PhD, is Director of Academic Affairs at the Cardiovascular Research Foundation and Co-Director of Transcatheter Cardiovascular Therapeutics (TCT). He is also Professor of Medicine at the Mount Sinai School of Medicine and Director of Cardiovascular Innovation at the Zena and Michael A. Wiener Cardiovascular Institute of the Mount Sinai Medical Center in New York.

Dr. Dangas currently serves as Chair of the American College of Cardiology (ACC) Interventional Scientific Council and has been a Trustee of the Society for Cardiovascular Angiography and Interventions (SCAI). He is a key faculty and program committee member for multiple international conferences including the ACC/i2 Summit, AHA, ACCIS, JIM, and SCAI. He also recently joined the Board of Trustees of the ACC.

Before joining the faculty of Mount Sinai, Dr. Dangas was Associate Professor and Program Director of Interventional Cardiology at Columbia University Medical Center in New York and Associate Clinical Professor at New York University School of Medicine and Lenox Hill Hospital.

Dr. Dangas completed medical and postgraduate studies at the National Kapodistrian University of Athens, Greece. He finished his internship and residency in internal medicine at Miriam Hospital and Brown University in Providence, Rhode Island. He also fulfilled cardiovascular disease and interventional cardiology fellowships at Mount Sinai Hospital. 

Philippe Généreux, MD, is Director of the Angiographic Core Laboratory at the CRF Clinical Trials Center. The Angiographic Core Laboratory is part of CRFiCOR, one of the world’s leading imaging core laboratories. Dr. Généreux has served and is currently serving as the primary or co-investigator on more than 20 clinical trials and has been published more than 300 times in peer-reviewed cardiology journals. His areas of expertise include coronary risk stratification/Syntax score, coronary physiology and imaging, percutaneous aortic valve replacement, transradial intervention, drug-eluting stent innovation, and medical simulation. He is also Co-Director of the Structural Heart Program at Morristown Medical Center and a practicing interventional cardiologist at Hôpital du Sacré-Coeur de Montréal in Canada. He received his medical degree from the Université de Montréal, Québec, Canada.

Juan F. Granada, MD, is the Executive Director and Chief Innovation Officer of the CRF Skirball Center for Innovation. He is also an Assistant Professor of Medicine at Columbia University College of Physicians and Surgeons. 

Dr. Granada is one of the world’s foremost investigators in the study of animal models of atherosclerosis, advanced endovascular imaging, and emerging cardiovascular therapies. He has helped develop and successfully validate several endovascular imaging and device technologies.

Dr. Granada received his medical degree from the Institute of Health Sciences in Medellin, Colombia and finished his internship and residency in internal medicine at the Marshfield Clinic in Wisconsin where he also served as chief medical resident. He completed his cardiovascular disease and interventional cardiology fellowships at Baylor College of Medicine in Houston, Texas. 

Greg L. Kaluza MD, PhD, is the Director of Research at the CRF Skirball Center for Innovation. He has extensive expertise in guiding early ideas and inventions through comprehensive research programs to introduce practical therapies into clinical cardiovascular medicine.

Prior to CRF, Dr. Kaluza served as Scientific Director of the Center for Research in Cardiovascular Interventions and as Co-Director of the Angiographic Core Laboratory at the Methodist Hospital Research Institute in Houston, Texas. He received his medical degree from the Nicolas Copernicus Academy of Medicine in Kraków, Poland. He completed his postgraduate fellowship at the Laboratory of Physiology, University of Antwerp, Belgium, and his residency in internal medicine at the Jagiellonian University College of Medicine, Kraków, Poland.   

Ajay J. Kirtane, MD, SM, is Associate Professor of Medicine at Columbia University Medical Center and Director of the Cardiac Catheterization Laboratories at NewYork-Presbyterian Hospital/Columbia University Medical Center. Dr. Kirtane is a practicing cardiologist with an interest in coronary and peripheral intervention and assumed the directorship of the NYPH/CUMC cardiac catheterization laboratories in 2015. In addition to his clinical commitments at CUMC, Dr. Kirtane has a strong interest in clinical education and research, serving as Chief Academic Officer of the Center for Interventional Vascular Therapy and Director of the Interventional Cardiology Fellowship Training Program.

On the national and international level, he is a co-director of CRF’s Transcatheter Cardiovascular Therapeutics meeting, has served as a director of several international, national, and regional educational meetings, and has participated on the program committees for the scientific sessions of both the American College of Cardiology and American Heart Association. Dr. Kirtane’s research interests are in clinical trial methodology and outcomes of device-based and pharmacologic interventions in interventional cardiology. He has authored or co-authored more than 150 original manuscripts and over 50 reviews and chapters including the “Coronary Stenting” chapters of the two most widely used textbooks in interventional cardiology. He has been principal investigator for several multicenter trials of interventional devices and serves on the steering committees of several large-scale clinical trials in interventional cardiovascular medicine.

 Dr. Kirtane is a graduate of Princeton University and Columbia University College of Physicians and Surgeons, and completed his residency/chief residency in internal medicine at the University of California, San Francisco. He completed fellowships in cardiovascular disease and coronary and peripheral vascular intervention at Beth Israel Deaconess Medical Center/Harvard Medical School and has a Master’s of Science in Clinical Epidemiology from the Harvard School of Public Health.

Ioanna Kosmidou, MD, PhD, is Director of Safety at the CRF Clinical Trials Center. A board certified cardiologist and electrophysiologist, Dr. Kosmidou joined CRF in 2015 as Associate Director, Clinical Development. She completed her residency in internal medicine at Tufts University/St. Elizabeth’s Medical Center and her cardiology fellowship at Emory University in Atlanta, followed by a subspecialty fellowship in electrophysiology at the Brigham and Women’s Hospital in Boston. Dr. Kosmidou received her medical degree from the University of Patras and PhD from Athens University, both in Greece.

Akiko Maehara, MD, is the Director of the Intravascular Imaging Core Laboratory at the CRF Clinical Trials Center. She is also an Assistant Professor of Medicine at Columbia University College of Physicians and Surgeons in New York. She is a leading authority in the field of intravascular imaging and physiology.

Dr. Maehara received her medical degree from Yamaguchi University School of Medicine in Yamaguchi, Japan. She completed her clinical fellowship in the Toranomon Hospital in Tokyo, Japan, and a cardiovascular fellowship at the Cardiovascular Center in Toranomon Hospital, also in Tokyo. Dr. Maehara finished a research fellowship in cardiovascular interventions at Stanford University School of Medicine in Stanford, California, with an additional year of fellowship in the Cardiovascular Research Institute at the Washington Hospital Center in Washington, DC.

Roxana Mehran, MD, is Chief Scientific Officer of the CRF Clinical Trials Center and a Co-Director of Transcatheter Cardiovascular Therapeutics (TCT). She is also Professor of Medicine at Mount Sinai School of Medicine and Director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Wiener Cardiovascular Institute.

Dr. Mehran is internationally renowned for her work as a clinical trial specialist with complex data analyses and outcomes research within the field of interventional cardiovascular medicine. She currently serves on the board of trustees of the Society for Cardiovascular Angiography and Interventions (SCAI) and is a member of the Program Committee for the American Heart Association Scientific Sessions. She is also the co-founder and Program Chair of SCAI's Women in Innovations (WIN), a global initiative aimed at creating and strengthening research, educational, and professional opportunities for female interventional cardiologists.

Dr. Mehran was previously Associate Professor of Medicine and Director of Outcomes Research, Data Coordination and Analysis at the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center. She completed her training in internal medicine at the University of Connecticut, where she was Chief Medical Resident before continuing her studies in cardiovascular diseases and interventional cardiology at Mount Sinai Medical Center in New York. 

*Also part of the management team.

Physician Contributors