CRF Skirball Center for Innovation

Our History

For over 20 years, Skirball Center for Innovation has contributed to key advances in the treatment of cardiovascular disease and played an essential role in bringing innovative new technologies, pharmacologic therapies, and treatment paradigms to patients.

The CRF Skirball Center for Innovation opens.
The first physician training is held.
The inaugural first-in- man study is performed using technology whose key preclinical testing was performed at the CRF Skirball Center for Innovation.
The first live broadcast of investigational technology is transmitted to the Main Arena at TCT.

The first Good Laboratory Practices (GLP) study is performed.

The CRF Skirball Center for Innovation core imaging laboratory opens.

The first IDE is granted based predominantly on GLP studies performed at the CRF Skirball Center for Innovation.

A landmark paper published by Murata validates the utility of optical coherence tomography (OCT) in the evaluation of stents.
The first report is published on the use of the familial hypercholesterolemic (Rapacz) swine in testing of coronary drug-eluting stent efficacy.

The first report is published on the predictive value of the familial hypercholesterolemic (Rapacz) swine in assessing the efficacy of drug-coated balloons.
The first FDA market approval is granted for a technology whose key preclinical testing was performed entirely at the CRF Skirball Center for Innovation.
FDA audit of the CRF Skirball Center for Innovation concludes with no deficiencies noted.
The CRF Skirball Center for Innovation hosts an exclusive Skirball Symposium on drug-coated balloon technologies.

A total of 20 different technologies evaluated preclinically at the CRF Skirball Center for Innovation have reached the first-in-man phase or received CE Mark, IDE, or FDA market clearance.

The CRF Skirball Center for Innovation surpasses 100 abstracts presented at interventional cardiology conferences worldwide
The CRF Visual Interactive Technology Center (VITC) is launched at TCT 2014.
The inaugural CRF Interventional Innovation Award is presented at TCT 2014. The winning technology was chosen from more than 50 entries

The CRF Skirball Center for Innovation celebrates its 10-year Anniversary.
CRF Skirball Center for Innovation conducts physician training immediately preceding first-in-man applications.
The Visual Interactive Training Center is renamed Interactive Training Center for remote (virtual) and in-person physician and allied healthcare personnel training sessions
The CRF Skirball Center for Innovation gathers a group of worldwide experts to vet novel technologies in the first-ever Innovation Shark Tank competition at TCT 2015.

Publications

Our leadership continually furthers the field by regularly contributing articles to world-renowned medical journals.

2015

Gongora CA, Shibuya M, Wessler JD, McGregor J, Tellez A, Cheng Y, Conditt GB, Kaluza GL, Granada JF. Impact of paclitaxel dose on tissue pharmacokinetics and vascular healing: a comparative drug-coated balloon study in the familial hypercholesterolemic swine model of superficial femoral in-stent restenosis. JACC Cardiovasc Interv. 2015; 8: 1115-23.

Cortese B, Granada JF, Scheller B, Schneider PA, Tepe G, Scheinert D, Garcia L, Stabile E, Alfonso F, Ansel G, Zeller T. Drug-coated balloon treatment for lower extremity vascular disease intervention: an international positioning document. Eur Heart J. 2015 May 24. pii: ehv204. [Epub ahead of print]

Suter MJ, Kashiwagi M, Gallagher KA, Nadkarni SK, Asanani N, Tanaka A, Conditt GB, Tellez A, Milewski K, Kaluza GL, Granada JF, Bouma BE, Tearney GJ. Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study. Int J Cardiovasc Imaging. 2015; 31: 1097-106.

Cheng Y, Yi GH, Annest LS, Van Bladel K, Brown R, Wechsler A, Shibuya M, Conditt GB, Peppas A, Kaluza GL, Granada JF. Early feasibility evaluation of thoracoscopically assisted transcatheter ventricular reconstruction in an experimental model of ischaemic heart failure with left anteroapical aneurysm. EuroIntervention. 2015; 10: 1480-7.

Gongora CA, Shibuya M, Ramzipoor K, Lee C, Cheng Y, McGregor JC, Estrada EA, Granada JF, Kaluza GL. Vessel caging versus vascular restoration in the same artery: long-term vascular remodeling and healing in response to overlapping metal stent and bioresorbable polymer scaffold. JACC Cardiovasc Interv. 2015; 8: 631-2.

Schneider PA, Giasolli R, Ebner A, Virmani R, Grananda JF. Early experimental and clinical experience with a focal implant for lower extremity post-angioplasty dissection. JACC Cardiovasc Interv. 2015; 8: 347-54.

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