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Pulmonary Hypertension

When high blood pressure occurs in the pulmonary vessels surrounding the lungs, it causes shortness of breath, chest pain, dizziness, and other symptoms. This chronic medical condition can be inherited, associated with other diseases or conditions, or may be idiopathic, meaning its exact cause is unknown.

Medical therapy and surgery can help many patients with pulmonary hypertension, but as the disease progresses, catheter-based interventions may be used either to alleviate symptoms or to act as a “bridge” until the patient can receive a lung transplant or less commonly, a heart-lung transplant. One such procedure, called an atrial septostomy, involves using a balloon to widen the space between the right and left atriums of the heart to improve blood flow.

CRF is committed to advancing cardiovascular research and improving care for patients with heart disease. Using our vast experience and expertise, we are focused on developing technologies, therapies, and treatments for disease states such as pulmonary hypertension.

Relevant CTC Service Areas for Pulmonary Hypertension

  • Trial Design
  • Protocol Development
  • Data Management
  • Statistics And Programming
  • Hemodynamic Core Lab
  • CT Core Lab
  • CEC
  • DSMB
  • Medical Writing
  • Extended Database Management and Analysis

Click here to request more information about CTC services

Heart Failure

Congestive heart failure (CHF) is a condition in which blood flow and pressure provided by the heart are not sufficient to meet the needs of the body.  CHF is most commonly caused by left, right, or biventricular dysfunction.  In many patients, heart failure is a result of coronary artery disease or pathologies of the heart valves.

While lifestyle modification and medications are critical to the treatment of CHF, surgery and device-based therapies are often indicated. For example, different types of pacemakers, implantable cardioverter defibrillator (ICDs) and cardiac resynchronization (CRT) devices, can be used to regulate rapid or slow heartbeats, or to help the heart beat stronger. Non-invasive as well as implantable pressure sensors are used to help tailor treatment. Clinical evaluation of left atrial pressure lowering devices is currently underway. Lastly, a mechanical pump, called a left ventricular assist device (LVAD), can be implanted to assist the heart in pumping blood.

CRF physicians have extensive experience in treating heart failure and performing basic and clinical studies to bring such therapies to patients. The CTC recently created a new Heart Failure, Hemodynamics and Circulatory Support department focused on CHF research initiatives.  We aim to support the regulatory and clinical trial needs of sponsors investigating new drug- and device-based treatments for heart failure at all stages of development.

Relevant CTC Service Areas for Heart Failure

  • Trial Design
  • Protocol Development
  • Data Management
  • Statistics And Programming
  • Echocardiography Core Lab
  • Hemodynamic Core Lab
  • CT Core Lab
  • CEC
  • DSMB
  • Medical Writing
  • Extended Database Management and Analysis

Click here to request more information about CTC services

Hyperlipidemia

Patients diagnosed with hyperlipidemia have cholesterol and triglyceride levels that put them at risk for atherosclerotic cardiovascular disease and heart attacks.

Managing hyperlipidemia begins with behavioral changes including diet, exercise, quitting smoking, and maintaining a healthy weight. When these efforts are not enough, medications may help. The most common of these drugs, statins, come in pill form. Additionally, injectable drugs that belong to a new class of agents called PCSK9 inhibitors have recently been approved to accompany diet and statin therapy in some patients who are unable to get their low-density lipoprotein cholesterol under control or who cannot tolerate statins.

CRF is committed to advancing cardiovascular research and improving care for patients with heart disease. Using our vast clinical, scientific, and unique imaging expertise, we are focused on developing technologies, therapies, and treatments for disease states such as hyperlipidemia.

Relevant CTC Service Areas for Hyperlipidemia

  • Trial Design
  • Protocol Development
  • Data Management
  • Statistics And Programming
  • IVUS Core Lab
  • OCT Core Lab
  • Angiographic Core Lab
  • CEC
  • DSMB
  • Medical Writing
  • Extended Database Management and Analysis

Click here to request more information about CTC services

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